Microbially derived polyunsaturated fatty acid as a modulator of gastrointestinal motility

Yang Xiao, Purna C. Kashyap

Research output: Contribution to journalReview articlepeer-review


Gastrointestinal (GI) motility requires coordination among several cell types in the intestinal epithelium and the neuromuscular apparatus. A disruption in GI motility was primarily attributed to disruption of this coordinated effort among different host cells, but recent studies have begun to uncover how the products of gut microbiota can alter GI motility by modulating the function of different host cells and the interactions among them. In this issue of the JCI, Chen, Qiu, et al. used a reverse translation approach, isolating a Shigella sp. - peristaltic contraction-inhibiting bacterium (PIB) - from a cohort of patients with intractable constipation. They identified an ω-3 polyunsaturated fatty acid (PUFA), docosapentaenoic acid (DPA), produced by this Shigella variant, as an important driver of constipation using a series of microbiologic, biochemical, and genetic manipulations combined with in vitro and in vivo studies. This finding advances the field, given that production of DPA is rare in the human gut and appears to have a distinct effect on GI physiology.

Original languageEnglish (US)
Article numbere161572
JournalJournal of Clinical Investigation
Issue number14
StatePublished - Jul 15 2022

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Microbially derived polyunsaturated fatty acid as a modulator of gastrointestinal motility'. Together they form a unique fingerprint.

Cite this