TY - JOUR
T1 - Methods for gene expression profiling in clinical trials of adjuvant breast cancer therapy
AU - Paik, Soonmyung
AU - Brown, Myles
AU - Ingle, James
AU - Dowsett, Mitch
AU - Johnston, Stephen
AU - Buzdar, Aman
AU - Winer, Eric
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Although endocrine therapy is highly effective in the treatment of endocrine receptor-positive breast cancer, chemotherapy has been shown to provide clinical benefit when added to tamoxifen. However, baseline risk after tamoxifen treatment is so low, especially in patients who are axillary node negative, that significant overtreatment will result if chemotherapy is given to every patient. Robust prognostic and predictive markers need to be developed to identify those at high risk of treatment failure. Although comprehensive gene expression profiling methods do offer promise, they require fresh or frozen tumor samples. To take advantage of existing archived tissue blocks with clinical follow-up collected from finished clinical trials, such as National Surgical Adjuvant Breast and Bowel Project trials B-20 and B-14, technologies that allow interrogation of archived blocks for gene expression profiling need to be realized. Recent developments in gene expression profiling technologies are discussed with their implications in clinical management of endocrine receptor-positive breast cancer.
AB - Although endocrine therapy is highly effective in the treatment of endocrine receptor-positive breast cancer, chemotherapy has been shown to provide clinical benefit when added to tamoxifen. However, baseline risk after tamoxifen treatment is so low, especially in patients who are axillary node negative, that significant overtreatment will result if chemotherapy is given to every patient. Robust prognostic and predictive markers need to be developed to identify those at high risk of treatment failure. Although comprehensive gene expression profiling methods do offer promise, they require fresh or frozen tumor samples. To take advantage of existing archived tissue blocks with clinical follow-up collected from finished clinical trials, such as National Surgical Adjuvant Breast and Bowel Project trials B-20 and B-14, technologies that allow interrogation of archived blocks for gene expression profiling need to be realized. Recent developments in gene expression profiling technologies are discussed with their implications in clinical management of endocrine receptor-positive breast cancer.
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U2 - 10.1158/1078-0432.CCR-05-2296
DO - 10.1158/1078-0432.CCR-05-2296
M3 - Article
C2 - 16467119
AN - SCOPUS:32944463609
SN - 1078-0432
VL - 12
SP - 1019s-1023s
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 3 II
ER -