Methods and Challenges in Quantitative Imaging Biomarker Development

Richard G. Abramson, Kirsteen R. Burton, John Paul J. Yu, Ernest M. Scalzetti, Thomas E. Yankeelov, Andrew B. Rosenkrantz, Mishal Mendiratta-Lala, Brian J. Bartholmai, Dhakshinamoorthy Ganeshan, Leon Lenchik, Rathan M. Subramaniam

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Academic radiology is poised to play an important role in the development and implementation of quantitative imaging (QI) tools. This article, drafted by the Association of University Radiologists Radiology Research Alliance Quantitative Imaging Task Force, reviews current issues in QI biomarker research. We discuss motivations for advancing QI, define key terms, present a framework for QI biomarker research, and outline challenges in QI biomarker development. We conclude by describing where QI research and development is currently taking place and discussing the paramount role of academic radiology in this rapidly evolving field.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalAcademic radiology
Issue number1
StatePublished - Jan 1 2015


  • Biomarker development
  • Quantitative imaging
  • Radiology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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