Metastatic spinal cord compression: A survival score particularly developed for elderly prostate cancer patients

Dirk Rades, Antonio J. Conde-Moreno, Jon Cacicedo, Barbara Segedin, Theo Veninga, Steven E. Schild

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Aim: Metastatic spinal cord compression (MSCC) is an oncological emergency. Many elderly patients cannot tolerate intensive treatment and need individual approaches accounting for a patient's remaining lifetime. The goal of the present study was to develop a survival score for elderly prostate cancer patients with MSCC. Patients and Methods: Nine characteristics were analyzed in 243 patients: age, performance status, interval from prostate cancer diagnosis until MSCC, affected vertebrae, ambulatory status, further bone lesions, visceral metastases, time developing motor deficits, fractionation schedule. Results: Pre-radiotherapy ambulatory status (p<0.001), visceral metastases (p<0.001) and time developing motor deficits (p<0.001) were significant for survival on Cox regression analysis and included in the survival score. Four groups were defined: 9-12, 13-16, 17-19 and 21-23 points. Six-month survival rates were 7%, 28%, 71% and 95%, respectively (p<0.001). Conclusion: The present study identified four groups with different survival probabilities that require treatment strategies with different priorities ranging from symptom control to prolongation of life.

Original languageEnglish (US)
Pages (from-to)6189-6192
Number of pages4
JournalAnticancer research
Issue number11
StatePublished - Nov 2015


  • Elderly patients
  • Irradiation
  • Metastatic epidural spinal cord compression
  • Overall survival
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Metastatic spinal cord compression: A survival score particularly developed for elderly prostate cancer patients'. Together they form a unique fingerprint.

Cite this