TY - JOUR
T1 - Metabolomic signatures for drug response phenotypes
T2 - Pharmacometabolomics enables precision medicine
AU - Kaddurah-Daouk, R.
AU - Weinshilboum, R.
N1 - Publisher Copyright:
© 2015 American Society for Clinical Pharmacology and Therapeutics.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - The scaling up of data in clinical pharmacology and the merger of systems biology and pharmacology has led to the emergence of a new discipline of Quantitative and Systems Pharmacology (QSP). This new research direction might significantly advance the discovery, development, and clinical use of therapeutic drugs. Research communities from computational biology, systems biology, and biological engineering - working collaboratively with pharmacologists, geneticists, biochemists, and analytical chemists - are creating and modeling large data on drug effects that is transforming our understanding of how these drugs work at a network level. In this review, we highlight developments in a new and rapidly growing field - pharmacometabolomics - in which large biochemical data-capturing effects of genome, gut microbiome, and environment exposures is revealing information about metabotypes and treatment outcomes, and creating metabolic signatures as new potential biomarkers. Pharmacometabolomics informs and complements pharmacogenomics and together they provide building blocks for QSP.
AB - The scaling up of data in clinical pharmacology and the merger of systems biology and pharmacology has led to the emergence of a new discipline of Quantitative and Systems Pharmacology (QSP). This new research direction might significantly advance the discovery, development, and clinical use of therapeutic drugs. Research communities from computational biology, systems biology, and biological engineering - working collaboratively with pharmacologists, geneticists, biochemists, and analytical chemists - are creating and modeling large data on drug effects that is transforming our understanding of how these drugs work at a network level. In this review, we highlight developments in a new and rapidly growing field - pharmacometabolomics - in which large biochemical data-capturing effects of genome, gut microbiome, and environment exposures is revealing information about metabotypes and treatment outcomes, and creating metabolic signatures as new potential biomarkers. Pharmacometabolomics informs and complements pharmacogenomics and together they provide building blocks for QSP.
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U2 - 10.1002/cpt.134
DO - 10.1002/cpt.134
M3 - Article
C2 - 25871646
AN - SCOPUS:84940545374
SN - 0009-9236
VL - 98
SP - 71
EP - 75
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 1
ER -