Metabolism as a guiding force for immunity

Jonathan Jung; Hu Zeng; Tiffany Horng

doi:10.1038/s41556-018-0217-x

Metabolism as a guiding force for immunity

Jonathan Jung, Hu Zeng, Tiffany Horng

Rheumatology

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

Recent studies indicate that cellular metabolism plays a key role in supporting immune cell maintenance and development. Here, we review how metabolism guides immune cell activation and differentiation to distinct cellular states, and how differential regulation of metabolism allows for context-dependent support during activation and lineage commitment. We discuss emerging principles of metabolic support of immune cell function in physiology and disease, as well as their general relevance to the field of cell biology.

Original language	English (US)
Pages (from-to)	85-93
Number of pages	9
Journal	Nature Cell Biology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1038/s41556-018-0217-x
State	Published - Jan 1 2019

ASJC Scopus subject areas

Cell Biology

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abstract = "Recent studies indicate that cellular metabolism plays a key role in supporting immune cell maintenance and development. Here, we review how metabolism guides immune cell activation and differentiation to distinct cellular states, and how differential regulation of metabolism allows for context-dependent support during activation and lineage commitment. We discuss emerging principles of metabolic support of immune cell function in physiology and disease, as well as their general relevance to the field of cell biology.",

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Metabolism as a guiding force for immunity

Abstract

ASJC Scopus subject areas

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