Metabolic Profile in Neonatal Pig Hearts

Pengsheng Li; Fan Li; Ling Tang; Wenjing Zhang; Yan Jin; Haiwei Gu; Wuqiang Zhu

doi:10.3389/fcvm.2021.763984

Metabolic Profile in Neonatal Pig Hearts

Pengsheng Li, Fan Li, Ling Tang, Wenjing Zhang, Yan Jin, Haiwei Gu, Wuqiang Zhu

Cardiovascular Diseases

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the metabolic profile in pig hearts at postnatal day 1, 3, 7, and 28 (P1, P3, P7, and P28, respectively) using a targeted liquid chromatography tandem mass spectrometry assay. Our data showed that there is a clear separation of the detected metabolites in P1 vs. P28 hearts. Active anabolisms of nucleotide and proteins were observed in P1 hearts when cardiomyocytes retain high cell cycle activity. However, the active posttranslational protein modification, metabolic switch from glucose to fatty acids, and the reduced ratio of collagen to total protein were observed in P28 hearts when cardiomyocytes withdraw from cell cycle.

Original language	English (US)
Article number	763984
Journal	Frontiers in Cardiovascular Medicine
Volume	8
DOIs	https://doi.org/10.3389/fcvm.2021.763984
State	Published - 2021

Keywords

heart
metabolism
metabolomics
neonatal
pig

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.3389/fcvm.2021.763984

Cite this

@article{9787b091066a4c95a22e65f23f713cbc,

title = "Metabolic Profile in Neonatal Pig Hearts",

abstract = "We evaluated the metabolic profile in pig hearts at postnatal day 1, 3, 7, and 28 (P1, P3, P7, and P28, respectively) using a targeted liquid chromatography tandem mass spectrometry assay. Our data showed that there is a clear separation of the detected metabolites in P1 vs. P28 hearts. Active anabolisms of nucleotide and proteins were observed in P1 hearts when cardiomyocytes retain high cell cycle activity. However, the active posttranslational protein modification, metabolic switch from glucose to fatty acids, and the reduced ratio of collagen to total protein were observed in P28 hearts when cardiomyocytes withdraw from cell cycle.",

keywords = "heart, metabolism, metabolomics, neonatal, pig",

author = "Pengsheng Li and Fan Li and Ling Tang and Wenjing Zhang and Yan Jin and Haiwei Gu and Wuqiang Zhu",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 Li, Li, Tang, Zhang, Jin, Gu and Zhu.",

year = "2021",

doi = "10.3389/fcvm.2021.763984",

language = "English (US)",

volume = "8",

journal = "Frontiers in Cardiovascular Medicine",

issn = "2297-055X",

publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - Metabolic Profile in Neonatal Pig Hearts

AU - Li, Pengsheng

AU - Li, Fan

AU - Tang, Ling

AU - Zhang, Wenjing

AU - Jin, Yan

AU - Gu, Haiwei

AU - Zhu, Wuqiang

PY - 2021

Y1 - 2021

N2 - We evaluated the metabolic profile in pig hearts at postnatal day 1, 3, 7, and 28 (P1, P3, P7, and P28, respectively) using a targeted liquid chromatography tandem mass spectrometry assay. Our data showed that there is a clear separation of the detected metabolites in P1 vs. P28 hearts. Active anabolisms of nucleotide and proteins were observed in P1 hearts when cardiomyocytes retain high cell cycle activity. However, the active posttranslational protein modification, metabolic switch from glucose to fatty acids, and the reduced ratio of collagen to total protein were observed in P28 hearts when cardiomyocytes withdraw from cell cycle.

AB - We evaluated the metabolic profile in pig hearts at postnatal day 1, 3, 7, and 28 (P1, P3, P7, and P28, respectively) using a targeted liquid chromatography tandem mass spectrometry assay. Our data showed that there is a clear separation of the detected metabolites in P1 vs. P28 hearts. Active anabolisms of nucleotide and proteins were observed in P1 hearts when cardiomyocytes retain high cell cycle activity. However, the active posttranslational protein modification, metabolic switch from glucose to fatty acids, and the reduced ratio of collagen to total protein were observed in P28 hearts when cardiomyocytes withdraw from cell cycle.

KW - heart

KW - metabolism

KW - metabolomics

KW - neonatal

KW - pig

UR - http://www.scopus.com/inward/record.url?scp=85146845397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85146845397&partnerID=8YFLogxK

U2 - 10.3389/fcvm.2021.763984

DO - 10.3389/fcvm.2021.763984

M3 - Article

AN - SCOPUS:85146845397

SN - 2297-055X

VL - 8

JO - Frontiers in Cardiovascular Medicine

JF - Frontiers in Cardiovascular Medicine

M1 - 763984

ER -

Metabolic Profile in Neonatal Pig Hearts

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this