Metabolic changes in aging humans: current evidence and therapeutic strategies

Allyson K. Palmer, Michael D. Jensen

Research output: Contribution to journalReview articlepeer-review


Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated by a sedentary lifestyle and can be in part prevented by maintenance of activity with aging. Here we explore the age-related changes seen in individual metabolic tissues — adipose, muscle, and liver — as well as globally in older adults. We also discuss the available evidence for therapeutic interventions such as caloric restriction, resistance training, and senolytic and senomorphic drugs to maintain healthy metabolism with aging, focusing on data from human studies.

Original languageEnglish (US)
Article numbere158451
JournalJournal of Clinical Investigation
Issue number16
StatePublished - Aug 15 2022

ASJC Scopus subject areas

  • Medicine(all)


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