Mental health conditions diagnosed before bilateral oophorectomy: A population-based case-control study

Liliana Gazzuola Rocca, Carin Y. Smith, William V. Bobo, Brandon R. Grossardt, Elizabeth A. Stewart, Shannon K. Laughlin-Tommaso, Walter A. Rocca

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective:We studied eight mental health conditions diagnosed before bilateral oophorectomy performed for nonmalignant indications.Methods:We identified 1,653 premenopausal women who underwent bilateral oophorectomy for a nonmalignant indication in Olmsted County, Minnesota, during a 20-year period (1988-2007). Each woman was matched by age (±1 year) to one population-based control who had not undergone bilateral oophorectomy before the index date (age range: 21-49 years). Both cases and controls were identified using the records-linkage system of the Rochester Epidemiology Project (REP For eight mental health conditions, we calculated odds ratios (ORs) and their 95% confidence intervals (95% CIs) adjusted for race, education, and income using conditional logistic regression.Results:Pre-existing mood disorders, anxiety disorders, and somatoform disorders were associated with increased risk of bilateral oophorectomy in overall analyses. These associations were also significant in women ≤45 years of age at index date. Personality disorders were associated with increased risk only in overall analyses and adjustment disorders only in women 46 to 49 years of age. Some of the associations were significantly different across strata by age at index date and by indication. There was also a linear trend of increasing adjusted ORs from 1.55 (95% CI 1.31-1.83) for one mental health condition to 2.19 (95% CI 1.40-3.41) for three or more conditions (trend P<0.001).Conclusions:We identified several mental health conditions that were associated with bilateral oophorectomy for nonmalignant indications. Awareness of these associations may guide women and physicians in future decision-making and limit unindicated bilateral oophorectomies. Video Summary:

Original languageEnglish (US)
Pages (from-to)1395-1404
Number of pages10
Issue number12
StatePublished - Dec 1 2019


  • Anxiety disorders
  • Bilateral oophorectomy
  • Mental health
  • Mood disorders
  • Personality disorders
  • Somatoform disorders

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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