Membranous nephropathy associated with angiomatoid fibrous histiocytoma in a pediatric patient

Mira A. Kohorst, Cheryl L. Tran, Andrew L. Folpe, Sanjeev Sethi, Carola A.S. Arndt

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Though membranous nephropathy is a much more common cause of nephrotic syndrome in the adult population, it accounts for only a small fraction of cases in pediatrics.

Conclusions: This case highlights a novel and treatable secondary cause of membranous nephropathy. Because secondary causes are more common in children than in adults, a high index of suspicion for other underlying pathology including malignancy should be considered. It also suggests that urinalysis may be a helpful screening tool in cases of angiomatoid fibrous histiocytoma.

Case-Diagnosis/Treatment: We report a case of a 16-year-old boy with nephrotic syndrome due to membranous nephropathy in the setting of a rare tumor, angiomatoid fibrous histiocytoma. This patient’s nephrotic-range proteinuria completely resolved following resection of this tumor. Angiomatoid fibrous histiocytoma, while known to cause other paraneoplastic syndromes such as anemia, has never been reported to cause membranous nephropathy.

Original languageEnglish (US)
Pages (from-to)2221-2224
Number of pages4
JournalPediatric Nephrology
Issue number11
StatePublished - Nov 2014

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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