Membranoproliferative glomerulonephritis, adult

Mariam P. Alexander, Sanjeev Sethi

Research output: Chapter in Book/Report/Conference proceedingChapter


Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury seen in varied disease conditions, and in itself does not refer to a specific disease entity. Previously it was classified according to the ultrastructural location of deposits as MPGN type I, II or III. Since then, we have moved onto a classification based on etiology and pathogenesis. The two broad pathogenetic pathways include either glomerular injury secondary to an immune complex/ monoclonal immunoglobulin deposition or consequent to complement deposition in the setting of dysregulated abnormalities of the complement system. Appropriate classification based on immunofluorescence permits a detailed and tailored evaluation for underlying infections, autoimmune diseases, monoclonal gammopathy and/or abnormalities of the complement system. Recent use of ancillary diagnostic techniques such as pronase immunflourescence and mass spectrometry promote accurate diagnosis in challenging cases.

Original languageEnglish (US)
Title of host publicationGlomerulonephritis
PublisherSpringer International Publishing
Number of pages17
ISBN (Electronic)9783319493794
ISBN (Print)9783319493787
StatePublished - Feb 26 2019


  • Autoimmune diseases
  • C3 glomerulopathy
  • Complement
  • Immune complex
  • Infections
  • MPGN
  • Monoclonal immunoglobulin

ASJC Scopus subject areas

  • General Medicine


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