Melatonin responsive hemicrania continua

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Hemicrania continua is one of the indomethacin-responsive headache syndromes. There are very few effective alternative therapies for hemicrania continua, thus patients may require daily indomethacin for years. The risks of long-term indomethacin include gastrointestinal and renal dysfunction. Melatonin is a pineal hormone with a chemical structure very similar to indomethacin. Recently, melatonin was shown to be effective for primary stabbing headache, another indomethacin-responsive syndrome. Three cases of melatonin responsive hemicrania continua are now reported.

Original languageEnglish (US)
Pages (from-to)1203-1204
Number of pages2
Issue number7
StatePublished - Jul 2006


  • Hemicrania continua
  • Indomethacin
  • Melatonin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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