Meige syndrome in the spectrum of lewy body disease

Margery H. Mark, J. I. Sage, D. W. Dickson, R. E. Heikkila, L. Manzino, K. O. Schwarz, R. C. Duvoisin

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


We report a patient with Meige syndrome (segmental cranial dystonia) who had neuropathology changes of Parkinson’s disease on postmortem examination. Neuropathologic examination showed typical and atypical Lewy bodies in the pigmented nuclei of the brainstem (substantia nigra, locus ceruleus), the nucleus basalis of Meynert, and the nucleus ambiguus. Neurochemical analysis of postmortem brain tissue showed evidence for decreased dopamine turnover in the substantia nigra, striatum, and nucleus accumbens. We propose that some cases of Meige syndrome may be included in the spectrum of Lewy body disease.

Original languageEnglish (US)
Pages (from-to)1432-1436
Number of pages5
Issue number8
StatePublished - Aug 1994

ASJC Scopus subject areas

  • Clinical Neurology


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