TY - JOUR
T1 - Meeting the Challenges of Myocarditis
T2 - New Opportunities for Prevention, Detection, and Intervention—A Report from the 2021 National Heart, Lung, and Blood Institute Workshop
AU - on behalf of the Workshop Speakers
AU - Čiháková, Daniela
AU - Shi, Yang
AU - Adhikari, Bishow
AU - Bandettini, W. Patricia
AU - Cunningham, Madeleine W.
AU - Danthi, Narasimhan
AU - Friedrich, Matthias G.
AU - Liu, Peter
AU - Longacre, Lisa Schwartz
AU - Mann, Douglas L.
AU - Swirski, Filip K.
AU - Tang, W. H.Wilson
AU - Zhou, Guofei
AU - Cooper,, Leslie T.
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of international experts to discuss new research opportunities for the prevention, detection, and intervention of myocarditis in May 2021. These experts reviewed the current state of science and identified key gaps and opportunities in basic, diagnostic, translational, and therapeutic frontiers to guide future research in myocarditis. In addition to addressing community-acquired myocarditis, the workshop also focused on emerging causes of myocarditis including immune checkpoint inhibitors and SARS-CoV-2 related myocardial injuries and considered the use of systems biology and artificial intelligence methodologies to define workflows to identify novel mechanisms of disease and new therapeutic targets. A new priority is the investigation of the relationship between social determinants of health (SDoH), including race and economic status, and inflammatory response and outcomes in myocarditis. The result is a proposal for the reclassification of myocarditis that integrates the latest knowledge of immunological pathogenesis to refine estimates of prognosis and target pathway-specific treatments.
AB - The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of international experts to discuss new research opportunities for the prevention, detection, and intervention of myocarditis in May 2021. These experts reviewed the current state of science and identified key gaps and opportunities in basic, diagnostic, translational, and therapeutic frontiers to guide future research in myocarditis. In addition to addressing community-acquired myocarditis, the workshop also focused on emerging causes of myocarditis including immune checkpoint inhibitors and SARS-CoV-2 related myocardial injuries and considered the use of systems biology and artificial intelligence methodologies to define workflows to identify novel mechanisms of disease and new therapeutic targets. A new priority is the investigation of the relationship between social determinants of health (SDoH), including race and economic status, and inflammatory response and outcomes in myocarditis. The result is a proposal for the reclassification of myocarditis that integrates the latest knowledge of immunological pathogenesis to refine estimates of prognosis and target pathway-specific treatments.
KW - NHLBI workshop in myocarditis
KW - cardiac magnetic resonance
KW - cytokines
KW - dilated cardiomyopathy
KW - heart biopsy
KW - heart failure
KW - lymphocytes
KW - macrophages
KW - myocarditis
KW - viral myocarditis
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U2 - 10.3390/jcm11195721
DO - 10.3390/jcm11195721
M3 - Article
AN - SCOPUS:85139913077
SN - 2077-0383
VL - 11
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 19
M1 - 5721
ER -