Medulla Oblongata Hemorrhage and Reverse Takotsubo Cardiomyopathy

Kevin T. Gobeske, Maurice E Sarano, Jennifer E. Fugate, Eelco F. Wijdicks

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Acute brain injury with strong surges of adrenergic outflow has resulted in takotsubo cardiomyopathy, but there are surprisingly few reports of takotsubo cardiomyopathy after intracranial hemorrhage, and none have been described from hemorrhage within the brainstem. Results: We describe a patient with reverse and reversible cardiomyopathy following a hemorrhage in the lateral medulla oblongata. While it is limited in size, the location of the hemorrhage caused acute systolic failure with left ventricular ejection fraction of 27% and vasopressor requirement for cardiogenic shock and pulmonary edema. There was full recovery after 7 days. Methods: Detailed case report. Conclusion: Hemorrhage into medulla oblongata pressor centers may result in acute, reversible, stress-induced cardiomyopathy, affirming the adrenergic origin of this condition.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeurocritical Care
StateAccepted/In press - Dec 19 2017


  • Intracranial hemorrhage
  • Medulla oblongata
  • Neurogenic cardiac injury
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


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