TY - JOUR
T1 - Mediators and regulation of peristalsis
AU - Grider, J. R.
AU - Foxx-Orenstein, A. E.
PY - 1999
Y1 - 1999
N2 - Peristalsis is the main postprandial propulsive activity of the gut. It is mediated by neurons of the enteric nervous system, which form an integrated circuit composed of sensory neurons, modulatory interneurons, and motor neurons to the circular and longitudinal muscle layers. Work outlined in this review has identified, by anatomic, physiologic, and pharmacologic techniques, the myenteric neurons and neurotransmitters involved in the regulation of this reflex. Of particular note are studies identifying the role of 5-hydroxytryptamine4 (5-HT4) receptors in the initiation of the peristaltic reflex and the development of selective 5-HT4 agonists as potential therapeutic agents.
AB - Peristalsis is the main postprandial propulsive activity of the gut. It is mediated by neurons of the enteric nervous system, which form an integrated circuit composed of sensory neurons, modulatory interneurons, and motor neurons to the circular and longitudinal muscle layers. Work outlined in this review has identified, by anatomic, physiologic, and pharmacologic techniques, the myenteric neurons and neurotransmitters involved in the regulation of this reflex. Of particular note are studies identifying the role of 5-hydroxytryptamine4 (5-HT4) receptors in the initiation of the peristaltic reflex and the development of selective 5-HT4 agonists as potential therapeutic agents.
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U2 - 10.1097/00001574-199901000-00005
DO - 10.1097/00001574-199901000-00005
M3 - Short survey
C2 - 17023913
AN - SCOPUS:0033056714
SN - 0267-1379
VL - 15
SP - 22
EP - 25
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 1
ER -