Mechanisms underlying thrombocytopenia in the neonatal intensive care unit

M. C. Sola, L. M. Rimsza

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Thrombocytopenia is one of the most common hematological problems among neonates in the neonatal intensive care unit (NICU), but in the majority of cases the kinetic mechanism responsible is unclear. This review focuses on both traditional and innovative methods used to evaluate the mechanisms responsible for thrombocytopenia in neonates, and analyzes the data generated from those methods. Conclusion: Results of studies using new methods for evaluating thrombocytopenia, coupled with recent descriptions of marrow megakaryocyte mass, suggest that decreased platelet production complicates most cases of thrombocytopenia among neonates in the NICU.

Original languageEnglish (US)
Pages (from-to)66-73
Number of pages8
JournalActa Paediatrica, International Journal of Paediatrics, Supplement
Issue number438
StatePublished - 2002


  • Bone marrow
  • Megakaryocyte progenitors
  • Megakaryocytes
  • Neonatal thrombocytopenia
  • Platelet kinetics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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