Abstract
T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and cancer and in impairing the response to vaccination. Easy accessibility to peripheral human T cells as well as an expanding array of tools to examine T cell biology have provided opportunities to examine major ageing pathways and their consequences for T cell function. Here, we review emerging concepts of how the body attempts to maintain a functional T cell compartment with advancing age, focusing on three fundamental domains of the ageing process, namely self-renewal, control of cellular quiescence and cellular senescence. Understanding these critical elements in successful T cell ageing will allow the design of interventions to prevent or reverse ageing-related T cell failure.
Original language | English (US) |
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Pages (from-to) | 573-583 |
Number of pages | 11 |
Journal | Nature Reviews Immunology |
Volume | 19 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2019 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology