Mechanisms and metabolic implications of regional differences among fat depots

Tamara Tchkonia, Thomas Thomou, Yi Zhu, Iordanes Karagiannides, Charalabos Pothoulakis, Michael D. Jensen, James L. Kirkland

Research output: Contribution to journalReview articlepeer-review

314 Scopus citations


Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex, genetic background, disease state, certain drugs and hormones, development, and aging. Preadipocyte replication and differentiation, developmental gene expression, susceptibility to apoptosis and cellular senescence, vascularity, inflammatory cell infiltration, and adipokine secretion vary among depots, as do fatty-acid handling and mechanisms of enlargement with positive-energy and loss with negative-energy balance. How interdepot differences in these molecular, cellular, and pathophysiological properties are related is incompletely understood. Whether fat redistribution causes metabolic disease or whether it is a marker of underlying processes that are primarily responsible is an open question.

Original languageEnglish (US)
Pages (from-to)644-656
Number of pages13
JournalCell Metabolism
Issue number5
StatePublished - May 7 2013

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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