Mechanism of lymph node metastasis in prostate cancer

Kaustubh Datta, Michael Muders, Heyu Zhang, Donald J. Tindall

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


Detection of lymph node metastases indicates poor prognosis for prostate cancer patients. Therefore, elucidation of the mechanism(s) of lymph node metastasis is important to understand the progression of prostate cancer and also to develop therapeutic interventions. In this article, the known mechanisms for lymph node metastasis are discussed and the involvement of lymphatic vessels in prostate cancer lymph node metastasis is comprehensively summarized. In addition, contradictory findings regarding the importance of lymphangiogenesis in facilitating lymph node metastasis in prostate cancer are pointed out and reconcilation is attempted.

Original languageEnglish (US)
Pages (from-to)823-836
Number of pages14
JournalFuture Oncology
Issue number5
StatePublished - May 2010


  • Lymph node metastasis
  • Lymphangiogenesis
  • Prostate cancer
  • VEGF-C

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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