Measurements of acute cerebral infarction: Lesion size by computed tomography

Thomas Brott, John R. Marler, Charles P. Olinger, Harold P. Adams, Thomas Tomsick, William G. Barsan, José Biller, Robert Eberle, Vicki Hertzberg, Michael Walker

Research output: Contribution to journalArticlepeer-review

298 Scopus citations


As part of a prospective therapy study of 65 patients with acute, nonhemorrhagic, cerebral infarction, computed tomographic scans of the head were obtained at admission, 7-10 days, and 3 months. The scans were analyzed for the presence, site, size, and volume measurement of the infarction. At 7-10 days, the mean infarction volume as measured by computed tomography was 55 cm3 or about 4×4×3.5 cm (range=0 507 cm3). At 3 months, the mean infarction volume decreased by 25% to 41 cm3. For the 26 scans showing infarction at the time of admission, the mean lesion volume was 33 cm3 at admission, 51 cm3 at 7-10 days, and 49 cm3 at 3 months. With lesion size at 7-10 days expressed as percentage of total brain volume, the mean infarction size was only 5%. Of the 49 patients with lesions revealed by computed tomography at 7-10 days, 20 had an infarction of 1% or less of total brain volume, while only six had an infarction of 20% or more of total brain volume. The lesion volumes as measured by the 7-10-day computed tomography correlated with the neurologic examination scores on admission (Spearman’s rank-order correlation=0.78) and with the scores at 1 week (Spearman’s rank-order correlation=0.79).

Original languageEnglish (US)
Pages (from-to)871-875
Number of pages5
Issue number7
StatePublished - Jul 1989


  • Cerebral infarction
  • Emission computed
  • Neurologic examination
  • Tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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