TY - JOUR
T1 - Measurements of acute cerebral infarction
T2 - Lesion size by computed tomography
AU - Brott, Thomas
AU - Marler, John R.
AU - Olinger, Charles P.
AU - Adams, Harold P.
AU - Tomsick, Thomas
AU - Barsan, William G.
AU - Biller, José
AU - Eberle, Robert
AU - Hertzberg, Vicki
AU - Walker, Michael
PY - 1989/7
Y1 - 1989/7
N2 - As part of a prospective therapy study of 65 patients with acute, nonhemorrhagic, cerebral infarction, computed tomographic scans of the head were obtained at admission, 7-10 days, and 3 months. The scans were analyzed for the presence, site, size, and volume measurement of the infarction. At 7-10 days, the mean infarction volume as measured by computed tomography was 55 cm3 or about 4×4×3.5 cm (range=0 507 cm3). At 3 months, the mean infarction volume decreased by 25% to 41 cm3. For the 26 scans showing infarction at the time of admission, the mean lesion volume was 33 cm3 at admission, 51 cm3 at 7-10 days, and 49 cm3 at 3 months. With lesion size at 7-10 days expressed as percentage of total brain volume, the mean infarction size was only 5%. Of the 49 patients with lesions revealed by computed tomography at 7-10 days, 20 had an infarction of 1% or less of total brain volume, while only six had an infarction of 20% or more of total brain volume. The lesion volumes as measured by the 7-10-day computed tomography correlated with the neurologic examination scores on admission (Spearman’s rank-order correlation=0.78) and with the scores at 1 week (Spearman’s rank-order correlation=0.79).
AB - As part of a prospective therapy study of 65 patients with acute, nonhemorrhagic, cerebral infarction, computed tomographic scans of the head were obtained at admission, 7-10 days, and 3 months. The scans were analyzed for the presence, site, size, and volume measurement of the infarction. At 7-10 days, the mean infarction volume as measured by computed tomography was 55 cm3 or about 4×4×3.5 cm (range=0 507 cm3). At 3 months, the mean infarction volume decreased by 25% to 41 cm3. For the 26 scans showing infarction at the time of admission, the mean lesion volume was 33 cm3 at admission, 51 cm3 at 7-10 days, and 49 cm3 at 3 months. With lesion size at 7-10 days expressed as percentage of total brain volume, the mean infarction size was only 5%. Of the 49 patients with lesions revealed by computed tomography at 7-10 days, 20 had an infarction of 1% or less of total brain volume, while only six had an infarction of 20% or more of total brain volume. The lesion volumes as measured by the 7-10-day computed tomography correlated with the neurologic examination scores on admission (Spearman’s rank-order correlation=0.78) and with the scores at 1 week (Spearman’s rank-order correlation=0.79).
KW - Cerebral infarction
KW - Emission computed
KW - Neurologic examination
KW - Tomography
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U2 - 10.1161/01.STR.20.7.871
DO - 10.1161/01.STR.20.7.871
M3 - Article
C2 - 2749847
AN - SCOPUS:0024312252
SN - 0039-2499
VL - 20
SP - 871
EP - 875
JO - Stroke
JF - Stroke
IS - 7
ER -