Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model

Chiara Dalla Man, Andrea Caumo, Rita Basu, Robert Rizza, Gianna Toffolo, Claudio Cobelli

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The oral glucose minimal model (OMM) measures insulin sensitivity (S I) and the glucose rate of appearance (Ra) of ingested glucose in the presence of physiological changes of insulin and glucose concentrations. However, SI of OMM measures the overall effect of insulin on glucose utilization and glucose production. In this study we show that, by adding a tracer to the oral dose, e.g., of a meal, and by using the labeled version of OMM, OMM* to interpret the data, one can measure the selective effect of insulin on glucose disposal, S*I Eighty-eight individuals underwent both a triple-tracer meal with the tracer-to-tracee clamp technique, providing a model-independent reference of the Ra of ingested glucose (Ra mealref) and an insulin-modified labeled intravenous glucose tolerance test (IVGTT*). We show that OMM* provides not only a reliable means of tracing the R a of ingested glucose (Ra meal) but also accurately measures S*I. We do so by comparing OMM* R a meal with the model-independent Ra mealref provided by the tracer-to-tracee clamp technique, while OMM* S*I is compared with both S*Iref, obtained by using as known input Ra mealref and with S*I measured during IVGTT*.

Original languageEnglish (US)
Pages (from-to)E909-E914
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number5 52-5
StatePublished - Nov 2005


  • Glucose utilization
  • Insulin action
  • Intravenous glucose tolerance test
  • Oral glucose tolerance test
  • Tracer-to-tracee activity clamp

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


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