Abstract
The acoustic nonlinearity parameter B A and sound speed c have been determined for excised normal and abnormal human livers at 20-37°C. These values are compared with analytic measurements of fat and water content of tissues. The results show that normal liver containing 71.0% water and 2.9% fat by weight has a B A value of 6.75 and sound speed of 1592 m/s at 37°C. Both these parameters increase at an average rate of 0.026°C and 1.5m/s/°C, respectively, as the temperature is raised from 20 to 37°C. Fatty liver (24% fat by weight) exhibits highest B A (9.12) and lowest c (1522 m/s) of all the livers studied. In contrast to normal livers sound speed in such a liver was found to decrease with temperature. Based on the acoustic and composition measurements, quantitative correlations of B A and c with fat-water composition have been developed. Inversion of these relationships provide a simple method to determine composition of a tissue sample from B A and c measurements.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 865-874 |
| Number of pages | 10 |
| Journal | Ultrasound in Medicine and Biology |
| Volume | 12 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1986 |
Keywords
- Acoustic nonlinearity
- B A
- Fat-water composition
- Human liver
- Sound speed
- Tissue characterization
ASJC Scopus subject areas
- Biophysics
- Radiological and Ultrasound Technology
- Acoustics and Ultrasonics