Measles Virus (Paramyxoviridae)

Roberto Cattaneo, Michael McChesney

Research output: Chapter in Book/Report/Conference proceedingChapter


Measles virus (MeV) is an immunosuppressive, extremely contagious RNA virus that remains one of the leading causes of death among children. Wild type MeV strains spread first in lymphatic tissues, causing immunosuppression, and then in epithelial cells of the upper airways, favoring extremely efficient transmission. MeV vaccines are based on a live attenuated strain that indiscriminately enters cells expressing a ubiquitous protein, rather than sequentially entering target tissues through specific receptors. Ectopic replication of the vaccine strain alarms the immune system, which prevents overt disease. Because of the availability of a highly effective vaccine MeV is a candidate for eradication.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Virology
Subtitle of host publicationVolume 1-5, Fourth Edition
Number of pages10
ISBN (Electronic)9780128145166
StatePublished - Jan 1 2020


  • Attenuation
  • Contagion
  • Host-exit receptor
  • Immunosuppression
  • Measles
  • Membrane fusion
  • Morbilliviruses
  • Nectin-4
  • Negative-strand RNA virus
  • Paramyxoviruses
  • Ribonucleocapsid
  • Signaling lymphocytic activation molecule
  • Tropism
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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