Measles Virus (Paramyxoviridae)

Roberto Cattaneo; Michael McChesney

doi:10.1016/B978-0-12-809633-8.21506-9

Measles Virus (Paramyxoviridae)

Roberto Cattaneo, Michael McChesney

Molecular Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Measles virus (MeV) is an immunosuppressive, extremely contagious RNA virus that remains one of the leading causes of death among children. Wild type MeV strains spread first in lymphatic tissues, causing immunosuppression, and then in epithelial cells of the upper airways, favoring extremely efficient transmission. MeV vaccines are based on a live attenuated strain that indiscriminately enters cells expressing a ubiquitous protein, rather than sequentially entering target tissues through specific receptors. Ectopic replication of the vaccine strain alarms the immune system, which prevents overt disease. Because of the availability of a highly effective vaccine MeV is a candidate for eradication.

Original language	English (US)
Title of host publication	Encyclopedia of Virology
Subtitle of host publication	Volume 1-5, Fourth Edition
Publisher	Elsevier
Pages	619-628
Number of pages	10
Volume	1-5
ISBN (Electronic)	9780128145166
DOIs	https://doi.org/10.1016/B978-0-12-809633-8.21506-9
State	Published - Jan 1 2020

Keywords

Attenuation
Contagion
Host-exit receptor
Immunosuppression
Measles
Membrane fusion
Morbilliviruses
Nectin-4
Negative-strand RNA virus
Paramyxoviruses
Ribonucleocapsid
Signaling lymphocytic activation molecule
Tropism
Vaccine

ASJC Scopus subject areas

Immunology and Microbiology(all)

Access to Document

10.1016/B978-0-12-809633-8.21506-9

Cite this

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abstract = "Measles virus (MeV) is an immunosuppressive, extremely contagious RNA virus that remains one of the leading causes of death among children. Wild type MeV strains spread first in lymphatic tissues, causing immunosuppression, and then in epithelial cells of the upper airways, favoring extremely efficient transmission. MeV vaccines are based on a live attenuated strain that indiscriminately enters cells expressing a ubiquitous protein, rather than sequentially entering target tissues through specific receptors. Ectopic replication of the vaccine strain alarms the immune system, which prevents overt disease. Because of the availability of a highly effective vaccine MeV is a candidate for eradication.",

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AU - McChesney, Michael

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AB - Measles virus (MeV) is an immunosuppressive, extremely contagious RNA virus that remains one of the leading causes of death among children. Wild type MeV strains spread first in lymphatic tissues, causing immunosuppression, and then in epithelial cells of the upper airways, favoring extremely efficient transmission. MeV vaccines are based on a live attenuated strain that indiscriminately enters cells expressing a ubiquitous protein, rather than sequentially entering target tissues through specific receptors. Ectopic replication of the vaccine strain alarms the immune system, which prevents overt disease. Because of the availability of a highly effective vaccine MeV is a candidate for eradication.

KW - Attenuation

KW - Contagion

KW - Host-exit receptor

KW - Immunosuppression

KW - Measles

KW - Membrane fusion

KW - Morbilliviruses

KW - Nectin-4

KW - Negative-strand RNA virus

KW - Paramyxoviruses

KW - Ribonucleocapsid

KW - Signaling lymphocytic activation molecule

KW - Tropism

KW - Vaccine

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BT - Encyclopedia of Virology

PB - Elsevier

ER -

Measles Virus (Paramyxoviridae)

Abstract

Keywords

ASJC Scopus subject areas

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