Measles virus causes immunogenic cell death in human melanoma

O. G. Donnelly, F. Errington-Mais, L. Steele, E. Hadac, V. Jennings, K. Scott, H. Peach, R. M. Phillips, J. Bond, H. Pandha, K. Harrington, R. Vile, S. Russell, P. Selby, A. A. Melcher

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma. This study demonstrates the efficacy of MV against human melanoma. It is increasingly recognised that an essential component of therapy with OV is the recruitment of host antitumour immune responses, both innate and adaptive. MV-mediated melanoma cell death is an inflammatory process, causing the release of inflammatory cytokines including type-1 interferons and the potent danger signal HMGB1. Here, using human in vitro models, we demonstrate that MV enhances innate antitumour activity, and that MV-mediated melanoma cell death is capable of stimulating a melanoma-specific adaptive immune response.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
JournalGene Therapy
Issue number1
StatePublished - Jan 2013


  • HMGB1
  • immunotherapy
  • interferon
  • measles
  • melanoma
  • oncolytic

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics


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