TY - JOUR
T1 - Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue
AU - Sternby, Hanna
AU - Mahle, Mariella
AU - Linder, Nicolas
AU - Erichson-Kirst, Laureen
AU - Verdonk, Robert C.
AU - Dimova, Alexandra
AU - Ignatavicius, Povilas
AU - Ilzarbe, Lucas
AU - Koiva, Peeter
AU - Penttilä, Anne
AU - Regnér, Sara
AU - Bollen, Thomas L.
AU - Brill, Richard
AU - Stangl, Franz
AU - Wohlgemuth, Walter A.
AU - Singh, Vijay
AU - Busse, Harald
AU - Michl, Patrick
AU - Beer, Sebastian
AU - Rosendahl, Jonas
N1 - Publisher Copyright:
© Author(s) 2019.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Background: Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective: The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. Methods: In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. Results: No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with p-values of 0.037 and 0.003 respectively. In multivariate analysis, low muscle attenuation was associated with severe AP with an odds ratio of 4.09 (95% confidence intervals: 1.61–10.36, p-value 0.003). No body parameter presented sufficient predictive capability in ROC-curve analysis. Conclusions: Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP.
AB - Background: Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective: The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. Methods: In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. Results: No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with p-values of 0.037 and 0.003 respectively. In multivariate analysis, low muscle attenuation was associated with severe AP with an odds ratio of 4.09 (95% confidence intervals: 1.61–10.36, p-value 0.003). No body parameter presented sufficient predictive capability in ROC-curve analysis. Conclusions: Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP.
KW - Acute pancreatitis
KW - mean muscle attenuation
KW - muscle mass
KW - severity
KW - visceral adipose tissue
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U2 - 10.1177/2050640619882520
DO - 10.1177/2050640619882520
M3 - Article
C2 - 31839956
AN - SCOPUS:85074115198
SN - 2050-6406
VL - 7
SP - 1312
EP - 1320
JO - United European Gastroenterology Journal
JF - United European Gastroenterology Journal
IS - 10
ER -