Abstract
Evidence from experimental autoimmune encephalomyelitis (EAE) suggests that CNS-infiltrating dendritic cells (DCs) are crucial for restimulation of coinfiltrating T cells. Here we systematically quantified and visualized the distribution and interaction of CNS DCs and T cells during EAE. We report marked periventricular accumulation of DCs and myelin-specific T cells during EAE disease onset prior to accumulation in the spinal cord, indicating that the choroid plexus-CSF axis is a CNS entry portal. Moreover, despite emphasis on spinal cord inflammation in EAE and in correspondence with MS pathology, inflammatory lesions containing interacting DCs and T cells are present in specific brain regions.
Original language | English (US) |
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Pages (from-to) | 39-49 |
Number of pages | 11 |
Journal | Journal of neuroimmunology |
Volume | 277 |
Issue number | 1-2 |
DOIs | |
State | Published - Dec 15 2014 |
Keywords
- Choroid plexus
- Dendritic cell
- Experimental autoimmune encephalomyelitis
- Multiple sclerosis
- Periventricular
- Rostral migratory stream
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology