Manual segmentation qualification platform for the EADC-ADNI harmonized protocol for hippocampal segmentation project

Simon Duchesne, Fernando Valdivia, Nicolas Robitaille, Abderazzak Mouiha, F. Abiel Valdivia, Martina Bocchetta, Liana G. Apostolova, Rossana Ganzola, Greg Preboske, Dominik Wolf, Marina Boccardi, Clifford R. Jack, Giovanni B. Frisoni

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: The use of hippocampal volumetry as a biomarker for Alzheimer's disease (AD) requires that tracers from different laboratories comply with the same segmentation method. Here we present a platform for training and qualifying new tracers to perform the manual segmentation of the hippocampus on magnetic resonance images (MRI) following the European Alzheimer's Disease Consortium and Alzheimer's Disease Neuroimaging Initiative (EADC-ADNI) Harmonized Protocol (HarP). Our objective was to demonstrate that the training process embedded in the platform leads to increased compliance and qualification with the HarP. Method: Thirteen new tracers' segmentations were compared with benchmark images with respect to: (a) absolute segmentation volume; (b) spatial overlap of contour with the reference using the Jaccard similarity index; and (c) spatial distance of contour with the reference. Point by point visual feedback was provided through three training phases on 10 MRI. Tracers were then tested on 10 different MRIs in the qualification phase. Results: Statistical testing of training over three phases showed a significant increase of Jaccard (i.e. mean Jaccard overlap P ,.001) between phases on average for all raters, demonstrating that training positively increased compliance with the HarP. Based on these results we defined qualification thresholds which all tracers were able to meet. Conclusions: This platform is an adequate infrastructure allowing standardized training and evaluation of tracers' compliance with the HarP. This is a necessary step allowing the use of hippocampal volumetry as a biomarker for AD in clinical and research centers.

Original languageEnglish (US)
Pages (from-to)161-174
Number of pages14
JournalAlzheimer's and Dementia
Issue number2
StatePublished - 2015


  • Alzheimer's disease
  • Area
  • Harmonized protocol
  • Hippocampal segmentation
  • Magnetic resonance imaging
  • Qualification platform
  • Qualitative criteria
  • Quantitative criteria
  • Spatial distance
  • Spatial overlap

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology


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