Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome

W. K. Eddie Ip, Kazue Takahashi, Kathryn J. Moore, Lynda M. Stuart, R. Alan B. Ezekowitz

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


Innate immunity is the first-line defense against pathogens and relies on phagocytes, soluble components, and cell-surface and cytosolic pattern recognition receptors. Despite using hard-wired receptors and signaling pathways, the innate immune response demonstrates surprising specificity to different pathogens. We determined how combinatorial use of innate immune defense mechanisms defines the response. We describe a novel cooperation between a soluble component of the innate immune system, the mannose-binding lectin, and Toll-like receptor 2 that both specifies and amplifies the host response to Staphylococcus aureus. Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways. JEM

Original languageEnglish (US)
Pages (from-to)169-181
Number of pages13
JournalJournal of Experimental Medicine
Issue number1
StatePublished - Jan 21 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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