Manifold medicine: A schema that expands treatment dimensionality

Choong Yong Ung, Taylor M. Weiskittel, Cristina Correia, Scott H. Kaufmann, Hu Li

Research output: Contribution to journalShort surveypeer-review


Drug discovery currently focuses on identifying new druggable targets and drug repurposing. Here, we illustrate a third domain of drug discovery: the dimensionality of treatment regimens. We formulate a new schema called ‘Manifold Medicine’, in which disease states are described by vectorial positions on several body-wide axes. Thus, pathological states are represented by multidimensional ‘vectors’ that traverse the body-wide axes. We then delineate the manifold nature of drug action to provide a strategy for designing manifold drug cocktails by design using state-of-the-art biomedical and technological innovations. Manifold Medicine offers a roadmap for translating knowledge gained from next-generation technologies into individualized clinical practice.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalDrug Discovery Today
Issue number1
StatePublished - Jan 2022


  • Combinatorial therapeutics
  • Individualized medicine
  • Manifold medicine
  • Systems pharmacology

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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