Managing High-Risk Breast Cancer

Frances M. Palmieri, Edith A. Perez

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objectives: To identify breast cancer patients at high risk for recurrence. To describe current evidence for clinical management of early and locally advanced breast cancer and integrate this knowledge into nursing practice. Data Sources: Articles, abstracts, and practice guidelines. Conclusion: Recent clinical trials have integrated the biology of breast cancer into individualized systemic therapy. Risk-adjusted treatment is driven by the addition of taxane therapy to systemic therapy, aromatase inhibitors, and trastuzumab into adjuvant therapy strategies. Implications for Nursing Practice: The decision to initiate systemic adjuvant therapy requires knowledge of risk of relapse, integration of evidence from clinical trials, and facilitation of patient decision-making.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalSeminars in Oncology Nursing
Issue number1
StatePublished - Feb 2007


  • Adjuvant trastuzumab trials
  • HER-2/neu
  • High-risk breast cancer
  • Locally advanced breast cancer

ASJC Scopus subject areas

  • Oncology(nursing)


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