TY - JOUR
T1 - Mammographic variation measures, breast density, and breast cancer risk
AU - Heine, John
AU - Fowler, Erin
AU - Scott, Christopher G.
AU - Jensen, Matthew R.
AU - Shepherd, John
AU - Hruska, Carrie B.
AU - Winham, Stacey J.
AU - Brandt, Kathleen R.
AU - Wu, Fang F.
AU - Norman, Aaron D.
AU - Pankratz, Vernon S.
AU - Miglioretti, Diana L.
AU - Kerlikowske, Karla
AU - Vachon, Celine M.
N1 - Publisher Copyright:
© American Roentgen Ray Society
PY - 2021/8
Y1 - 2021/8
N2 - OBJECTIVE. Our previous work showed that variation measures, which represent breast architecture derived from mammograms, were significantly associated with breast cancer. For replication purposes, we examined the association of three variation measures (variation [V], which is measured in the image domain, and P1 and p1 [a normalized version of P1] which are derived from restricted regions in the Fourier domain) with, breast cancer risk in an independent population. We also compared these measures to volumetric density measures (volumetric percent density [VPD] and dense volume [DV]) from a commercial product. MATERIALS AND METHODS. We examined 514 patients with breast cancer and 1377 control patients from a screening practice who were matched for age, date of examination, mammography unit, facility, and state of residence. Spearman rank-order correlation was used to evaluate the monotonic association between measures. Breast cancer associations were estimated using conditional logistic regression, after adjustment for age and body mass index. Odds ratios were calculated per SD increment in mammographic measure. RESULTS. These variation measures were strongly correlated with VPD (correlation, 0.68–0.80) but not with DV (correlation, 0.31–0.48). Similar to previous findings, all variation measures were significantly associated with breast cancer (odds ratio per SD: 1.30 [95% CI, 1.16–1.46] for V, 1.55 [95% CI, 1.35–1.77] for P1, and 1.51 [95% CI, 1.33–1.72] for p1). Associations of volumetric density measures with breast cancer were similar (odds ratio per SD: 1.54 [95% CI, 1.33–1.78] for VPD and 1.34 [95% CI, 1.20–1.50] for DV). When DV was included with each variation measure in the same model, all measures retained significance. CONCLUSION. Variation measures were significantly associated with breast cancer risk (comparable to the volumetric density measures) but were independent of the DV.
AB - OBJECTIVE. Our previous work showed that variation measures, which represent breast architecture derived from mammograms, were significantly associated with breast cancer. For replication purposes, we examined the association of three variation measures (variation [V], which is measured in the image domain, and P1 and p1 [a normalized version of P1] which are derived from restricted regions in the Fourier domain) with, breast cancer risk in an independent population. We also compared these measures to volumetric density measures (volumetric percent density [VPD] and dense volume [DV]) from a commercial product. MATERIALS AND METHODS. We examined 514 patients with breast cancer and 1377 control patients from a screening practice who were matched for age, date of examination, mammography unit, facility, and state of residence. Spearman rank-order correlation was used to evaluate the monotonic association between measures. Breast cancer associations were estimated using conditional logistic regression, after adjustment for age and body mass index. Odds ratios were calculated per SD increment in mammographic measure. RESULTS. These variation measures were strongly correlated with VPD (correlation, 0.68–0.80) but not with DV (correlation, 0.31–0.48). Similar to previous findings, all variation measures were significantly associated with breast cancer (odds ratio per SD: 1.30 [95% CI, 1.16–1.46] for V, 1.55 [95% CI, 1.35–1.77] for P1, and 1.51 [95% CI, 1.33–1.72] for p1). Associations of volumetric density measures with breast cancer were similar (odds ratio per SD: 1.54 [95% CI, 1.33–1.78] for VPD and 1.34 [95% CI, 1.20–1.50] for DV). When DV was included with each variation measure in the same model, all measures retained significance. CONCLUSION. Variation measures were significantly associated with breast cancer risk (comparable to the volumetric density measures) but were independent of the DV.
KW - Breast cancer
KW - Risk prediction
KW - Variation measures
KW - Volumetric breast density
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U2 - 10.2214/AJR.20.22794
DO - 10.2214/AJR.20.22794
M3 - Article
C2 - 34161135
AN - SCOPUS:85111185073
SN - 0361-803X
VL - 217
SP - 326
EP - 335
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 2
ER -