Malignant, predominantly lymphocytic thymoma with central and peripheral nervous system metastases

Mark R. Wick, William C. Nichols, James N. Ingle, James E. Bruckman, Haruo Okazaki

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Histologic features of an invasive mediastinal tumor found in a 25‐year‐old woman fulfilled the accepted criteria for diagnosis of predominantly lymphocytic thymoma. Histochemical and cell marker studies indicated that the neoplasm contained a preponderance of T lymphocytes. After surgical debulking of the mass, aggressive radiotherapy and chemotherapy eradicated all evidence of thoracic disease. However, six months after the initial diagnosis, rapid development of cranial nerve and brainstem metastases—without detectable recurrent disease elsewhere—resulted in the patient's death. Autopsy examination revealed the presence of peripheral nerve metastases as well. A review of the literature disclosed fewer than 10 cases of central nervous system metastasis from thymoma. In only two of these were there clinicopathologic features similar to those seen in this case.

Original languageEnglish (US)
Pages (from-to)2036-2043
Number of pages8
Issue number8
StatePublished - Apr 15 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Malignant, predominantly lymphocytic thymoma with central and peripheral nervous system metastases'. Together they form a unique fingerprint.

Cite this