Malignant peripheral nerve sheath tumor: The utility of fascicular biopsy and teased fiber studies

Jennifer A. Tracy, Devon I. Rubin, Kimberly K. Amrami, Robert J. Spinner, Janean K. Engelstad, Bernd W. Scheithauer, P. James B. Dyck

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


We present the case of a 67-year-old man with a malignant peripheral nerve sheath tumor (MPNST) affecting the brachial plexus. He presented with progressive right upper extremity paresthesias, numbness, weakness, and severe pain. Nerve conduction studies/electromyography demonstrated a right lower and middle trunk predominant brachial plexopathy. Three-tesla magnetic resonance imaging of the brachial plexus showed a soft tissue mass with central necrosis and cystic changes and irregular contrast enhancement. Positron emission tomography showed increased fluorodeoxyglucose uptake within the mass. Targeted fascicular nerve biopsy revealed hypercellular tumor, featuring atypical cells with mitotic figures and limited immunoreactivity for S-100 protein. The findings were those of an MPNST. The effects on the variably involved fascicles were also seen in teased fiber preparations, paraffin sections, and through immunohistochemistry. This case illustrates the presentation of this rare type of tumor, and characteristic neuroimaging and pathologic features of MPNSTs.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalJournal of clinical neuromuscular disease
Issue number1
StatePublished - Sep 2012


  • electrophysiology
  • malignant peripheral nerve sheath tumor
  • neurofibromatosis
  • neuroimaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Malignant peripheral nerve sheath tumor: The utility of fascicular biopsy and teased fiber studies'. Together they form a unique fingerprint.

Cite this