Major Hepatic Resection for Hilar Cholangiocarcinoma: Analysis of 46 Patients

David J. Rea, Manuel Munoz-Juarez, Michael B. Farnell, John H. Donohue, Florencia G. Que, Brian Crownhart, Dirk Larson, David M. Nagorney, John J. Brems, Ernest E. Moore, Stephen G. Remine, Mark Talamonti, Katherine J.M. Liu

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


Hypothesis: Major hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma are associated with actual long-term (>5 years) survival. Design: Retrospective outcome study. Setting: Single tertiary referral institution. Patients: Between 1979 and 1997, 46 consecutive patients had resection of hilar cholangiocarcinoma by major hepatectomy, bile duct resection, and regional lymphadenectomy. Main Outcome Measures: Overall survival and tumor recurrence were correlated to clinicopathological factors, operative morbidity, and mortality. Results: Twenty-five patients underwent left hepatectomy, 17 underwent right hepatectomy, and 4 had extended right hepatectomy. Eighteen patients underwent resection of segment 1. Negative (R0) resection margins were achieved in 37 patients (80%). The operative mortality rate was 9%, and the surgical morbidity rate was 52%. Actual 1-year, 3-year, and 5-year survival rates were 80%, 39%, and 26%, respectively. Factors adversely associated with patient survival rates included: male sex, lymph node metastases, tumor grade 3 or 4, elevated direct serum bilirubin level at diagnosis, elevated preoperative activated partial thromboplastin time, and more than 4 U of red blood cells transfused perioperatively. Tumor size and R0 resection approached significance for survival. Factors associated with tumor recurrence included: male sex, tumor grade 3 or 4, a low hemoglobin level both at diagnosis and preoperatively, and a low preoperative prothrombin time and low alkaline phosphatase level at diagnosis and preoperatively. Median time to recurrence was 3.6 years. Tumor recurrence was predominantly local and regional. Conclusions: The actual 5-year survival rate of 26% justifies major partial hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma. The high frequency of local and regional recurrence warrants investigation of adjuvant therapy.

Original languageEnglish (US)
Pages (from-to)514-525
Number of pages12
JournalArchives of Surgery
Issue number5
StatePublished - May 2004

ASJC Scopus subject areas

  • Surgery


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