Abstract
The effect of treadmill exercise on cell proliferation in the dentate gyrus was studied in Sprague-Dawley rats via 5-bromo-2′-deoxyuridine (BrdU)-specific immunohistochemistry. For studying the dependence of this effect on the magnitude of exercise, animals were divided into the control, light-exercise, moderate-exercise, and severe-exercise groups; different exercise regimens were applied to the groups. To study the temporal dependence of this effect, animals were divided into the control, 1-day-exercise, 3-days-exercise, 7-days-exercise, 14-days-exercise, and 28-days-exercise groups; the regimen used on the light-exercise group was applied to each of the exercise group over the respective number of days. Cell proliferation was most prominent in the light-exercise group (p < 0.001) and reached a maximum level after 7 days of exercise (p < 0.001). In this study, it was shown that cell proliferation is modulated by the intensity and duration of treadmill exercise.
Original language | English (US) |
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Pages (from-to) | 114-117 |
Number of pages | 4 |
Journal | International Journal of Sports Medicine |
Volume | 24 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2003 |
Keywords
- 5-bromo-2′-deoxyuridine
- Cell proliferation
- Dentate gyrus
- Exercise duration
- Exercise intensity
- Immunohistochemisty
- Treadmill exercise
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Orthopedics and Sports Medicine