TY - JOUR
T1 - Magnetic resonance spectroscopy at term-equivalent age in extremely preterm infants
T2 - Association with cognitive and language development
AU - Bapat, Roopali
AU - Narayana, Ponnada A.
AU - Zhou, Yuxiang
AU - Parikh, Nehal A.
N1 - Funding Information:
The funding agencies played no role in the design, conduct, or analysis of the trial. The authors take full responsibility for the integrity of the data and analyses. We sincerely thank Vipulkumar S. Patel, RT, for assistance with magnetic resonance imaging data acquisition. Grant funding was from National Center for Research Resources (NCRR) grant UL1 RR024148 (University of Texas Health Science Center at Houston Center for Clinical and Translational Sciences) and NCRR/Eunice Shriver National Institute of Child Health and Human Development grant UL1 RR024148-04S3 (Best Pharmaceuticals for Children Act), and the Research Institute at Nationwide Children's Hospital (NAP). The 3-T scanner was partially funded by NCRR/National Institutes of Health through a grant to Ponnada A. Narayana (grant S10 RR19186 ).
PY - 2014/7
Y1 - 2014/7
N2 - BACKGROUND: Proton magnetic resonance spectroscopy can be used to assess brain integrity and maturation with age. Objective To compare regional cerebral magnetic resonance spectroscopy metabolite ratios in extremely low birth weight and healthy term control infants measured at term-equivalent age and to evaluate association between magnetic resonance spectroscopy metabolites and cognitive and language development at 18-22 months' corrected age. METHODS: Single-voxel point-resolved spectroscopy sequence was performed in a prospective cohort of 43 infants. Magnetic resonance spectroscopy metabolite ratios of N-acetylaspartate to choline-containing compounds and N-acetylaspartate to myo-inositiol in the hippocampus, cortex, and subventricular zone were associated with Bayley mental, cognitive, and language scores at 18-22 months' corrected age. RESULTS: The mean (±S.D.) gestation of the 31 extremely low birth weight population was 25 (±1.1) weeks and mean (±S.D.) birth weight was 749 (±133.9) g. Compared with healthy term control infants, extremely low birth weight infants exhibited consistently lower N-acetylaspartate-to-choline- containing compounds ratios in our three regions of interest, with differences reaching statistical significance for the subventricular zone and cortex regions. In multiple linear regression analyses, N-acetylaspartate-to-choline- containing compounds ratio in the subventricular zone, N-acetylaspartate-to- choline-containing compounds ratio in the cortex, and N-acetylaspartate-to-myo- inositiol ratio in the subventricular zone were significantly associated with Bayley mental scores at 18-22 months' corrected age. CONCLUSIONS: Magnetic resonance spectroscopy metabolite abnormalities at term-equivalent age appear to be significantly associated with cognitive and language development in extremely low birth weight infants.
AB - BACKGROUND: Proton magnetic resonance spectroscopy can be used to assess brain integrity and maturation with age. Objective To compare regional cerebral magnetic resonance spectroscopy metabolite ratios in extremely low birth weight and healthy term control infants measured at term-equivalent age and to evaluate association between magnetic resonance spectroscopy metabolites and cognitive and language development at 18-22 months' corrected age. METHODS: Single-voxel point-resolved spectroscopy sequence was performed in a prospective cohort of 43 infants. Magnetic resonance spectroscopy metabolite ratios of N-acetylaspartate to choline-containing compounds and N-acetylaspartate to myo-inositiol in the hippocampus, cortex, and subventricular zone were associated with Bayley mental, cognitive, and language scores at 18-22 months' corrected age. RESULTS: The mean (±S.D.) gestation of the 31 extremely low birth weight population was 25 (±1.1) weeks and mean (±S.D.) birth weight was 749 (±133.9) g. Compared with healthy term control infants, extremely low birth weight infants exhibited consistently lower N-acetylaspartate-to-choline- containing compounds ratios in our three regions of interest, with differences reaching statistical significance for the subventricular zone and cortex regions. In multiple linear regression analyses, N-acetylaspartate-to-choline- containing compounds ratio in the subventricular zone, N-acetylaspartate-to- choline-containing compounds ratio in the cortex, and N-acetylaspartate-to-myo- inositiol ratio in the subventricular zone were significantly associated with Bayley mental scores at 18-22 months' corrected age. CONCLUSIONS: Magnetic resonance spectroscopy metabolite abnormalities at term-equivalent age appear to be significantly associated with cognitive and language development in extremely low birth weight infants.
KW - extremely low birth weight (ELBW) infants
KW - extremely preterm infants
KW - neurodevelopmental outcome
KW - proton magnetic resonance spectroscopy (MRS)
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U2 - 10.1016/j.pediatrneurol.2014.03.011
DO - 10.1016/j.pediatrneurol.2014.03.011
M3 - Article
C2 - 24938140
AN - SCOPUS:84902466361
SN - 0887-8994
VL - 51
SP - 53
EP - 59
JO - Pediatric Neurology
JF - Pediatric Neurology
IS - 1
ER -