Magnetic resonance appearance of peripheral nerve sheath tumors

Margaret A. Stull, Richard P. Moser, Mark J. Kransdorf, George P. Bogumill, Martha C. Nelson

Research output: Contribution to journalArticlepeer-review

164 Scopus citations


Magnetic resonance imaging (MRI) was used to evaluate 22 histologically proven peripheral nerve sheath tumors, approximately two-thirds of which arose in the lower extremity. The histologic distribution was as follows: 12 schwannomas, 7 neurofibromas, and 3 malignant peripheral nerve sheath tumors (2 of which occurred in patients with neurofibromatosis). Most lesions demonstrated an intermediate to moderately bright signal on T1-weighted images and were minimally inhomogeneous. All lesions were moderately bright on proton-density-weighted images and bright on T2-weighted images, again with variable inhomogeneity. The extent of the tumor was best assessed on proton-density- and T2-weighted images. Smooth margins were noted in 19 lesions. Of the 3 remaining lesions, 2 were malignant (but had been subjected to biopsy prior to MRI), and the other lesion was a plexiform neurofibroma. MRI accurately determined the relationship between the lesion and the adjacent neurovascular structures and muscles, thereby assisting surgical management. On MRI, 5 lesions demonstrated coexistent subtle muscle atrophy along the longitudinal axis of surrounding or distally innervated musculature. This latter finding, together with the presence of a tumor in the vicinity of a large nerve trunk, suggests a peripheral nerve sheath neoplasm.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalSkeletal Radiology
Issue number1
StatePublished - Jan 1991


  • Magnetic resonance
  • Neural tumors
  • Peripheral nerves

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Magnetic resonance appearance of peripheral nerve sheath tumors'. Together they form a unique fingerprint.

Cite this