Macrovascular disease: Pathobiology of endothelial function, renal artery remodeling, and plaque

Yoshiki Matsuo, Amir Lerman

Research output: Chapter in Book/Report/Conference proceedingChapter


Atherosclerotic renal vascular disease (ARVD) is the most common cause of renal artery stenosis. Endothelial dysfunction is a systemic disorder and a critical element in the pathogenesis of atherosclerotic lesions. Endothelial dysfunction leads to ARVD, and in turn, ARVD exacerbates systemic endothelial function, establishing a vicious circle. Intravascular ultrasound demonstrates that renal artery plaques have a wide variety of atherosclerotic phenotypes including vulnerable plaque features. The plaque characteristics of the renal artery are associated with the mode of arterial remodeling. With a more detailed understanding of the pathophysiology of the renal atherosclerotic plaque, the treatment strategies for atherosclerotic renal artery disease will continue to develop.

Original languageEnglish (US)
Title of host publicationRenal Vascular Disease
PublisherSpringer-Verlag London Ltd
Number of pages14
ISBN (Electronic)9781447128106
ISBN (Print)1447128095, 9781447128090
StatePublished - Dec 1 2014


  • Atherosclerosis
  • Endothelial dysfunction
  • Intravascular ultrasound
  • Remodeling
  • Renal artery plaque
  • Renal artery stenosis

ASJC Scopus subject areas

  • Medicine(all)


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