Abstract
Pancreatic inflammation is a risk factor for the development of pancreatic cancer. Increased presence of inflammatory macrophages can be found in response to a KRAS mutation in acinar cells or in response to experimentally-induced pancreatitis. Inflammatory macrophages induce pancreatic acinar cells to undergo dedifferentiation to a duct-like progenitor stage, a process called acinar-to-ductal metaplasia (ADM). Occurrence of ADM lesions are believed to be the initiating event in tumorigenesis. Here we will discuss how macrophage-induced oxidative stress contributes to ADM and how ADM cells shape the fibrotic stroma needed for further progression.
Original language | English (US) |
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Article number | 1278807 |
Journal | Frontiers in immunology |
Volume | 15 |
DOIs | |
State | Published - 2024 |
Keywords
- inflammatory
- initiation
- macrophage
- pancreatic cancer
- reactive oxygen species
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology