Lymphoreticular malignancy presenting as fulminant hepatic disease

Thomas V. Colby, Douglas R. LaBrecque

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Four cases of fulminant hepatic disease caused by lymphoreticular infiltration are described. All 4 patients died within a few weeks and clinical diagnoses included viral hepatitis, alcoholic hepatitis, and drug hepatitis. A diagnosis of malignancy was made prior to autopsy in only 1 of the 4 patients. Autopsies revealed typical malignant histiocytosis in 3 patients and the fourth had a primitive lymphoreticular malignancy with malignant histiocytosis the favored diagnosis. The extent of the liver infiltrate as judged histologically was mild compared with the severe clinical illness. Randomly scattered foci of necrosis associated with the malignant infiltrate were seen in the 2 patients who had marked elevations of serum glutamic oxaloacetic transaminase.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
Issue number2
StatePublished - Feb 1982

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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