Lymphoproliferative disease of granular T lymphocytes presenting as aplastic anemia

Ronald S. Go, Ayalew Tefferi, Chin Yang Li, John A. Lust, Robert L. Phyliky

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Lymphoproliferative disease of granular T lymphocyte (T-LDGL), also known as T-cell large granular lymphocyte leukemia, is a clonal disorder of cytotoxic T lymphocytes that is clinically manifested as chronic neutropenia and anemia. Association with autoimmune disorders is common. In 9 patients, T-LDGL is reported as presenting as aplasfic anemia. The clinical characteristics were similar to acquired aplastic anemia. Morphologic evidence of increased granular lymphocytes in the peripheral blood and an excess of CD3+/CD8+/CD57+ cells in the bone marrow were found in most cases. Cyclophosphamide was ineffective, but noncytotoxic immunosuppressive agents generally produced a good response. After a median follow-up of 49 months, 5 patients had died from the disease or related complications. Median survival was 40 months. Aplastic anemia can be a presenting manifestation of T-LDGL, and T-LDGL should be considered in the differential diagnosis of acquired aplastic anemia. (C) 2000 by The American Society of Hematology.

Original languageEnglish (US)
Pages (from-to)3644-3646
Number of pages3
Issue number10
StatePublished - Nov 15 2000

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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