Lymphoma-associated skin cancer: Incidence, natural history, and clinical management

Jerry D. Brewer, Thomas M. Habermann, Tait D. Shanafelt

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


The link between immunosuppression and skin cancer has been well described. The two most common situations involving immunosuppression-associated skin cancer are solid organ transplantation and non-Hodgkin lymphoma (NHL), including chronic lymphocytic leukemia (CLL). Patients with lymphoma are more likely to have development of a secondary malignancy, with skin cancer being the most common. The most common types of skin cancer in patients with NHL/CLL include melanoma, squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma. Many skin cancers demonstrate increased aggressiveness in patients with NHL/CLL and are associated with higher recurrence rates, increased regional metastasis, and death secondary to skin cancer metastases. This review delineates the current research regarding the relationship between NHL/CLL and cutaneous malignancy. Immunosuppressed patients with skin cancer should be treated promptly and aggressively to decrease recurrence and metastases. Regular skin self-examinations, dermatologic examinations, sun-protective habits, and education may prove beneficial in this high-risk patient population.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalInternational journal of dermatology
Issue number3
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Dermatology


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