Lymphocytic interstitial pneumonia: Thin-section CT findings in 22 patients

Takeshi Johkoh, Nestor L. Müller, Heather A. Pickford, Thomas E. Hartman, Kazuya Ichikado, Masanori Akira, Osamu Honda, Hironobu Nakamura

Research output: Contribution to journalArticlepeer-review

246 Scopus citations


PURPOSE: To assess the thin-section computed tomographic (CT) findings of lymphocytic interstitial pneumonia. MATERIALS AND METHODS: The study included 22 patients (five men, 17 women; age range, 24-83 years; mean age, 50 years) with biopsy-proved lymphocytic interstitial pneumonia. The CT scans were obtained by using 1-3-mm collimation and reconstructed by using a high- spatial-frequency algorithm. RESULTS: The predominant abnormalities consisted of areas of ground-glass attenuation and poorly defined centrilobular nodules present in all 22 patients and subpleural small nodules seen in 19 patients. Other common findings included thickening of bronchovascular bundles (n = 19), interlobular septal thickening (n = 18), cystic airspaces (n = 15), and lymph node enlargement (n = 15). Less common findings included large nodules, emphysema, airspace consolidation, bronchiectasis, architectural distortion, honeycombing, and pleural thickening. CONCLUSION: Lymphocytic interstitial pneumonia is characterized by the presence of ground-glass attenuation, poorly defined centrilobular nodules, and thickening of the interstitium along the lymphatic vessels. Lymph node enlargement is more common than previously recognized; it was seen in 68% of patients.

Original languageEnglish (US)
Pages (from-to)567-572
Number of pages6
Issue number2
StatePublished - Aug 1999


  • Acquired immunodeficiency syndrome (AIDS)
  • Castleman disease
  • Eye, diseases
  • Lung, CT
  • Pneumonitis, lymphocytic interstitial
  • Sjogren syndrome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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