James R. Taylor, Jay Ryu, Thomas V. Colby, Thomas A. Raffin

Research output: Contribution to journalArticlepeer-review

399 Scopus citations


MORE than 50 years ago, von Stössel reported unique autopsy findings in a 43-year-old woman who had died of respiratory failure: her lungs showed diffuse cystic changes and lymphadenopathy on gross examination, and a striking proliferation of smooth muscle throughout the lungs microscopically. He labeled the process muscular cirrhosis of the lungs.1 A few years later, Rosendal reported a similar case of “diffuse myomatosis and cyst formation in the lung.”2 These were among the first reported cases of what is now known as pulmonary lymphangioleiomyomatosis (LAM). This rare disorder affects only women, usually causes serious respiratory impairment, and continues to. . .

Original languageEnglish (US)
Pages (from-to)1254-1260
Number of pages7
JournalNew England Journal of Medicine
Issue number18
StatePublished - Nov 1 1990

ASJC Scopus subject areas

  • Medicine(all)


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