@inbook{81febc1eac0142b18be5f263da0f8152,
title = "Lung organogenesis",
abstract = "Developmental lung biology is a field that has the potential for significant human impact: lung disease at the extremes of age continues to cause major morbidity and mortality worldwide. Understanding how the lung develops holds the promise that investigators can use this knowledge to aid lung repair and regeneration. In the decade since the {"}molecular embryology{"} of the lung was first comprehensively reviewed, new challenges have emerged-and it is on these that we focus the current review. Firstly, there is a critical need to understand the progenitor cell biology of the lung in order to exploit the potential of stem cells for the treatment of lung disease. Secondly, the current familiar descriptions of lung morphogenesis governed by growth and transcription factors need to be elaborated upon with the reinclusion and reconsideration of other factors, such as mechanics, in lung growth. Thirdly, efforts to parse the finer detail of lung bud signaling may need to be combined with broader consideration of overarching mechanisms that may be therapeutically easier to target: in this arena, we advance the proposal that looking at the lung in general (and branching in particular) in terms of clocks may yield unexpected benefits.",
keywords = "Airway peristalsis, Branching morphogenesis, Developmental origins of adult disease, Mechanobiology, Regenerative medicine, Stem cells",
author = "David Warburton and Ahmed El-Hashash and Gianni Carraro and Caterina Tiozzo and Frederic Sala and Orquidea Rogers and Langhe, {Stijn De} and Kemp, {Paul J.} and Daniela Riccardi and John Torday and Saverio Bellusci and Wei Shi and Lubkin, {Sharon R.} and Edwin Jesudason",
note = "Funding Information: Funding sources: National Heart, Lung and Blood Institute, National Institutes of Health, USA, National Science Foundation, USA, California Institute for Regenerative Medicine, Medical Research Council UK, Biotechnology and Biological Sciences Research Council, UK, Foreign and Commonwealth Office UK/USA stem cell collaboration grant, American Heart Association, American Lung Association, and Pasadena Guild of Childrens Hospital Los Angeles. ",
year = "2010",
doi = "10.1016/S0070-2153(10)90003-3",
language = "English (US)",
series = "Current Topics in Developmental Biology",
publisher = "Academic Press Inc",
number = "C",
pages = "73--158",
booktitle = "Current Topics in Developmental Biology",
edition = "C",
}