Low‐grade squamous intraepithelial lesions: Cytologic predictors of biopsy Confirmation

Scott Hall, T. C. Wu, Naél Soudi, Mark E. Sherman

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


One hundred and seven smears demonstrating a low‐grade squamous intraepithelial lesion (LSIL) were analyzed for features predicting subsequent biopsy confirmation. Twelve (29%) of 41 smears showing few LSIL cells were biopsy confirmed compared to 33 (60%) of 55 containing an intermediate number of LSIL cells and 9 (82%) of 11 displaying many LSIL cells (P < 0.002). Thirty‐seven (47%) of 78 smears showing mainly condylomatous atypia (CA), 7 (54%) of 13 revealing predominantly cervical intraepithelial neoplasia 1 (CIN 1), and 10 (63%) of 16 displaying both CA and CIN 1 were histologically confirmed (N.S.). Biopsy confirmation was obtained in 35 (65%) of 54 women whose repeat smears obtained at colposcopy demonstrated SIL compared to four (15%) of 26 patients whose repeat smears were normal or contained atypical squamous cells of undetermined significance (P < 0.001). These results suggest that the number of diagnostic cells in an LSIL smear predicts biopsy confirmation and affirm the validity of combining CA and CIN 1 under the category of LSIL in the Bethesda System. © 1994 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalDiagnostic cytopathology
Issue number1
StatePublished - Feb 1994


  • Cervical carcinoma
  • Cervical intraepithelial neoplasia
  • Cervix
  • Colposcopy
  • Condyloma
  • Cytology
  • Human papillomavirus
  • In situ hybridization
  • Squamous intraepithelial lesion
  • The Bethesda System

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


Dive into the research topics of 'Low‐grade squamous intraepithelial lesions: Cytologic predictors of biopsy Confirmation'. Together they form a unique fingerprint.

Cite this