Lower gastrointestinal tract cancer predisposition syndromes

Neel B. Shah, Noralane M. Lindor

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Although inherited predisposition to colorectal cancer (CRC) has been suspected for more than 100 years, definitive proof of Mendelian syndromes had to await maturation of molecular genetic technologies. Since the l980s, the genetics of several clinically distinct entities has been revealed. Five disorders that share a hereditary predisposition to CRC are reviewed in this article.

Original languageEnglish (US)
Pages (from-to)1229-1252
Number of pages24
JournalHematology/Oncology Clinics of North America
Issue number6
StatePublished - Dec 2010


  • Cancer
  • Colorectal
  • Genetic syndrome
  • Lower GI
  • Risk

ASJC Scopus subject areas

  • Hematology
  • Oncology


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