Loss of pregnancy-associated plasma protein A extends lifespan in mice

Cheryl A. Conover; Laurie K. Bale

doi:10.1111/j.1474-9726.2007.00328.x

Loss of pregnancy-associated plasma protein A extends lifespan in mice

Cheryl A. Conover, Laurie K. Bale

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Genetic deletion in mice of pregnancy-associated plasma protein A (PAPP-A), a recently identified metalloproteinase in the insulin-like growth factor system, extends by 30-40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP-A as a critical regulator of lifespan and age-related diseases, and suggest PAPP-A as a possible target to promote longevity.

Original language	English (US)
Pages (from-to)	727-729
Number of pages	3
Journal	Aging Cell
Volume	6
Issue number	5
DOIs	https://doi.org/10.1111/j.1474-9726.2007.00328.x
State	Published - Oct 2007

Keywords

Gene knock-out
Insulin-like growth factor I
Longevity
Mouse model
Pregnancy-associated plasma protein A
Tumors

ASJC Scopus subject areas

Aging
Cell Biology

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10.1111/j.1474-9726.2007.00328.x

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AB - Genetic deletion in mice of pregnancy-associated plasma protein A (PAPP-A), a recently identified metalloproteinase in the insulin-like growth factor system, extends by 30-40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP-A as a critical regulator of lifespan and age-related diseases, and suggest PAPP-A as a possible target to promote longevity.

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KW - Mouse model

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KW - Tumors

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Loss of pregnancy-associated plasma protein A extends lifespan in mice

Abstract

Keywords

ASJC Scopus subject areas

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