Loss of pregnancy-associated plasma protein A extends lifespan in mice

Cheryl A. Conover, Laurie K. Bale

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Genetic deletion in mice of pregnancy-associated plasma protein A (PAPP-A), a recently identified metalloproteinase in the insulin-like growth factor system, extends by 30-40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP-A as a critical regulator of lifespan and age-related diseases, and suggest PAPP-A as a possible target to promote longevity.

Original languageEnglish (US)
Pages (from-to)727-729
Number of pages3
JournalAging Cell
Issue number5
StatePublished - Oct 2007


  • Gene knock-out
  • Insulin-like growth factor I
  • Longevity
  • Mouse model
  • Pregnancy-associated plasma protein A
  • Tumors

ASJC Scopus subject areas

  • Aging
  • Cell Biology


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