Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease

Kejal Kantarci, Stephen D. Weigand, Ronald C. Petersen, Bradley F. Boeve, David S. Knopman, Jeffrey Gunter, Denise Reyes, Maria Shiung, Peter C. O'Brien, Glenn E. Smith, Robert J. Ivnik, Eric G. Tangalos, Clifford R. Jack

Research output: Contribution to journalArticlepeer-review

143 Scopus citations


Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in 1H MR spectroscopy (1H MRS) metabolite markers have not been characterized in MCI subjects. Our objective was to determine the longitudinal 1H MRS metabolite changes in patients with MCI, and AD, and to compare 1H MRS metabolite ratios and ventricular volumes in tracking clinical disease progression in AD. The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly. The change in 1H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that 1H MRS metabolite ratios may be useful markers for the progression of AD. Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD.

Original languageEnglish (US)
Pages (from-to)1330-1339
Number of pages10
JournalNeurobiology of aging
Issue number9
StatePublished - Sep 2007


  • Alzheimer's disease
  • Choline
  • H MR spectroscopy
  • H MRS
  • Imaging
  • Longitudinal
  • Mild cognitive impairment
  • N-Acetylaspartate
  • Serial

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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